Technical Expert in Drug Carrier Fabrication

Expert technique en fabrication de transporteurs de médicaments. Rejoignez une équipe innovante pour des solutions non invasives.

TACHES

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Gérer la fabrication de transporteurs sensibles aux ultrasons. •
Améliorer le processus de fabrication des transporteurs. •
Établir la livraison de biologiques au cerveau avec ultrasons.



COMPETENCES



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Doctorat en biologie et expérience en biologie moléculaire requise. •



COMPETENCES


en chimie des transporteurs de médicaments. •
Maîtrise des contrôles de qualité en laboratoire. Technical Expert in Drug Carrier Fabrication
We are looking for a Technical Expert to join our focused ultrasound technology team for delivering drugs non-invasively to the brain using customized drug carriers. This position will support our recently developed Aggregation-Uncaging Focused Ultrasound (AU-FUS) technology for delivering drugs non-invasively to specific brain structures using customized drug carriers. The key objectives of this position are (1) to manage the fabrication and characterization of ultrasound-sensitive drug carriers, (2) improving the manufacturing process and (3) establish the delivery of biologics such as RNA to the brain using our ultrasound technology. Job description

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This role requires a very experienced technical specialist who can manage and oversee the complex chemical processes / synthesis necessary to produce the ultrasound-sensitive drug carriers, load them with different drugs and advance the process for loading, perform and maintain the quality control, and delivering biologics to the brain as well

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Besides overseeing this complex area, this position requires to summarize and present the status of the drug carrier fabrication in written and oral reports and performing the necessary statistical analyses for quality control

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This position requires a large level of autonomy to monitor established processes and improving / translating them into new modalities
Profile
Required skills:

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PhD in biology

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Approval to perform in-vivo experiments in the Canton of Zurich

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Very strong proficiency in drug carrier chemistry and synthesis

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Significant practical experience in molecular and RNA biology

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Understanding of focused ultrasound physics

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Experience in quality control and good laboratory / manufacturing practice (GLP/GMP)

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Experience in performing in-vivo tests and different animal behavior assays

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Demonstrated academic excellence (e. , high-impact publications)

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Experience writing scientific publications, reports and successful grant proposals

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Fluent in English
Nice to have:

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Experience with Prism / Graph pad or similar statistical software

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Experience and willingness to training junior staff (e. , drug carrier synthesis)

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Familiarity with different animal models of neuropsychiatric / neurological disorders
What we value:

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Research mindset and intellectual curiosity

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Ability to work independently

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Clear communication of ideas and results



WE OFFER



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Your job with impact: Become part of ETH Zurich, which not only supports your professional development, but also actively contributes to positive change in society

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You can expect numerous benefits, such as public transport season tickets and car sharing, a wide range of sports offered by the ASVZ, childcare and attractive pension benefits

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Perspectives for career development
Working, teaching and research at ETH Zurich (https://ethz. ch/en/the-eth-zurich/working-teaching-and-research. html)
We value diversity and sustainability
In line with
our values (https://ethz. ch/en/the-eth-zurich. html)
, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our
Equal Opportunities and Diversity website (https://ethz. ch/staffnet/en/employment-and-work/working-environment/diversity. html)
to find out how we ensure a fair and open environment that allows everyone to grow and flourish. Sustainability is a core value for us - we are consistently working towards a
climate-neutral future (https://ethz. ch/en/the-eth-zurich/sustainability. Curious? So are we. We look forward to receiving your online application with the following documents:

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A recent, detailed CV

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A brief description of your relevant experience and interests (max 1 page)

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Transcripts of all degrees (in English)

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Links to code repositories, publications, thesis (if possible) or projects (if available)

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Contact details of 2 relevant reference persons
Further information about Neurotechnology group can be found on our
website (https://neurotechnology. ch/)
: Questions regarding the position should be directed at
Write an email (https://www. ch/external/email-application/JUxhzPwxc3mXt0iHHxtU6g%3D%3D/a2ce8699-ba90-4154-82bc-226c4ce25883)
(no applications). Please submit the application documents using only the ETH online portal. Applications via email or postal services will not be considered. We evaluate applications on a rolling basis. About ETH Zürich
ETH Zurich is one of the world’s leading universities specialising in science and technology. We are renowned for our excellent education, cutting-edge fundamental research and direct transfer of new knowledge into society. Over 30,000 people from more than 120 countries find our university to be a place that promotes independent thinking and an environment that inspires excellence. Located in the heart of Europe, yet forging connections all over the world, we work together to develop solutions for the global challenges of today and tomorrow.